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Panda, Kanhu Charan
- Formulation and Evaluation of Immediate Release Tablets of Dasatinib using Croscarmelose Sodium
Abstract Views :156 |
PDF Views:3
Authors
Chinmaya Keshari Sahoo
1,
D. Venkata Ramana
2,
Nalinikanta Sahoo
3,
Kanhu Charan Panda
4,
Uttam Prasad Panigrahy
5
Affiliations
1 Department of Pharmaceutics, Malla Reddy College of Pharmacy, Maisammaguda, Hyderabad, Telangana-500014, IN
2 Department of Pharmaceutical Technology, Netaji Institute of Pharmaceutical Sciences, Toopranpet, Yadadri Bhongir, Telangana-508252, IN
3 Department of Pharmaceutical Analysis and Quality Assurance, MNR college of Pharmacy Fasalwadi, Sangareddy, Medak, Telangana, 502294, IN
4 Department of Pharmaceutics, Anwar-ul-Uloom College of Pharmacy, Rangareddy, Telangana, IN
5 Department of Pharmaceutical Analysis and Quality Assurance, Malla Reddy College of Pharmacy, Maisammaguda, Hyderabad, Telangana-500014, IN
1 Department of Pharmaceutics, Malla Reddy College of Pharmacy, Maisammaguda, Hyderabad, Telangana-500014, IN
2 Department of Pharmaceutical Technology, Netaji Institute of Pharmaceutical Sciences, Toopranpet, Yadadri Bhongir, Telangana-508252, IN
3 Department of Pharmaceutical Analysis and Quality Assurance, MNR college of Pharmacy Fasalwadi, Sangareddy, Medak, Telangana, 502294, IN
4 Department of Pharmaceutics, Anwar-ul-Uloom College of Pharmacy, Rangareddy, Telangana, IN
5 Department of Pharmaceutical Analysis and Quality Assurance, Malla Reddy College of Pharmacy, Maisammaguda, Hyderabad, Telangana-500014, IN
Source
Research Journal of Pharmacy and Technology, Vol 10, No 3 (2017), Pagination: 833-838Abstract
The objective of the present study was to develop an immediate release tablet of Dasatinib using different concentrations of cross carmelose sodium (CCS) as superdisintegrant with a view to gain rapid disintegration in gastric pH for treatment of chronic myeloid leukemia (CML) and acute myeloid leukemia (AML).Five different formulations of Dasatinib immediate release tablets were prepared using wet granulation method. Different pre compression and post compression characterization of tablet was carried out. In vitro drug release studies were carried out in USP II paddle type dissolution apparatus for different formulation and the batch containing 5% CCS gave maximum amount of drug release of 99.14%.Drug and excipients compatibility studies were carried out through FTIR spectroscopy. FTIR spectroscopy studies reveled that there is no interaction between drug and different excipients used in formulation. Short term stability studies (at 40±2°C/75±5% RH) on the best formulation indicated that there no significant changes in drug content.Keywords
Immediate Release Tablets, Dasatinib, CCS, in Vitro Drug Release Study, FTIR Spectroscopy.
- Formulation and Evaluation of Controlled Release Tablets of Aspirin
Abstract Views :182 |
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Authors
Affiliations
1 Department of Pharmaceutics, Malla Reddy College of Pharmacy, Maisammaguda, Secunderabad, Telangana-500014, IN
2 Department of Pharmacognosy, Princeton College of Pharmacy, Korremula, Ghatkesar, R. R. District, Telangana-500088, IN
3 Department of Pharmaceutical Technology, Netaji Institute of Pharmaceutical Sciences, Toopranpet, Yadadri Bhongir, Telangana-508252, IN
4 Department of Pharmaceutics, Anwarul Uloom College of Pharmacy, Newmallepally, Hyderabad, Telangana, IN
1 Department of Pharmaceutics, Malla Reddy College of Pharmacy, Maisammaguda, Secunderabad, Telangana-500014, IN
2 Department of Pharmacognosy, Princeton College of Pharmacy, Korremula, Ghatkesar, R. R. District, Telangana-500088, IN
3 Department of Pharmaceutical Technology, Netaji Institute of Pharmaceutical Sciences, Toopranpet, Yadadri Bhongir, Telangana-508252, IN
4 Department of Pharmaceutics, Anwarul Uloom College of Pharmacy, Newmallepally, Hyderabad, Telangana, IN
Source
Asian Journal of Pharmacy and Technology, Vol 7, No 4 (2017), Pagination: 229-233Abstract
The present work was aimed to develop controlled release tablets of aspirin. Direct compression technique was adopted for the preparation of all these formulations. The developed tablets were evaluated for pre compression parameters; post compression parameters, in vitro dissolution study. Among all the developed batches ASF3 showed highest drug release 96.14% at the end of 10 h. The optimized formulation was found to be stable up to 3 months when tested for stability study at 40±2ºC/ 75±5% RH.Keywords
Aspirin, Direct Compression, in vitro Drug Release, Stability Study.References
- Gul Majid Khan.Controlled release oral dosage forms:Some recent advances in matrix type of drug delivery system.Asian Journal of Pharmaceutical Sciences 2001;350-354.
- George M,Grass IV,Robinson J.Sustained and controlled release drug delivery systems chapter 6 Modern Pharmaceutics edited by Banker GS,Rhodes CT,2nd edn. Marcel Dekker, 1990; 639-658.
- Reddy PD,Swarnalatha D. Recent advances in novel drug delivery systems,International Journal of Pharma Tech Research 2010;2(3):2025-2027.
- Patrono C, Coller B, Dalen JE et al. Platelet-active drugs: the relationships among dose, effectiveness, and side effects. Chest. 2001; 119(1 suppl):39S– 63S
- Roth GJ, Majerus PW. The mechanism of the effect of aspirin on human platelets. I. Acetylation of a particulate fraction protein. J Clin Invest.1975; 56:624–32.
- V. Kalvimoorthi, N. Narasimhan. Formulation development and evaluation of aspirin delayed release tablets. International Journal of Pharmaceutical Sciences Review and Research 2011;7(1):27-32
- Kokkula Satyanarayana Chinmaya Keshari Sahoo, Gude Bhargavi and Nalini Kanta Sahoo Formulation and optimization of olanzapine sustained release matrix tablets for the treatment of schizophrenia. Der Pharmacia Lettre, 2015, 7 (4):266-273
- Sunil SA, Srikanth MV, Rao NS, Balaji S, Murthy KVR, Design and evaluation of lornoxicam bilayered tablets for biphasic release.Brajilian Journal of Pharmaceutical Sciences 2012;48(4):609-619.
- Sahoo CK, Sahoo NK, Rao SRM, Sudhakar M, Satyanarayana K.A review on controlled porosity osmotic pump tablets and its evaluation Bulletin of Faculty of Pharmacy, Cairo University 2015;53 (2):195-205
- Sahoo CK, Rao SRM, Sudhakar M., Satyanarayana K. Development and Evaluation of Controlled Release Formulation of Zidovudine Based on Microporous Osmotic Tablet Technology Using Fructose as Osmogen. Research J. Pharm. and Tech. 2017; 10(5): 1459-1470
- Sahoo CK,Rao SRM,Sudhakar M., Shashikala P,Formulation and Optimization of Controlled Porosity Osmotic Pump Tablets of Ritonavir, Journal of Chemical and Pharmaceutical Sciences, 2017; 10(3):1345-1352.
- Formulation Techniques for Designing of Osmotic Controlled Drug Delivery Systems:A Review
Abstract Views :217 |
PDF Views:0
Authors
Chinmaya Keshari Sahoo
1,
Surepalli Rammohan Rao
2,
Muvvala Sudhakar
3,
D. Venkata Ramana
4,
Kanhu Charan Panda
5
Affiliations
1 Department of Pharmaceutics, University College of Technology, Osmania University, Hyderabad, Telangana-500007., IN
2 Mekelle Institute of Technology, Mekelle University, Mekelle, ET
3 Department of Pharmaceutics, Malla Reddy College of Pharmacy (Affiliated to Osmania University), Maisammaguda, Secunderabad, Telangana-500014, IN
4 Department of Pharmaceutical Technology, Netaji Institute of Pharmaceutical Sciences, Toopranpet, Yadadri Bhongir, Telangana – 508252, IN
5 Department of Pharmaceutics, Anwarul Uloom College of Pharmacy, Newmallepally, Hyderabad, Telangana, IN
1 Department of Pharmaceutics, University College of Technology, Osmania University, Hyderabad, Telangana-500007., IN
2 Mekelle Institute of Technology, Mekelle University, Mekelle, ET
3 Department of Pharmaceutics, Malla Reddy College of Pharmacy (Affiliated to Osmania University), Maisammaguda, Secunderabad, Telangana-500014, IN
4 Department of Pharmaceutical Technology, Netaji Institute of Pharmaceutical Sciences, Toopranpet, Yadadri Bhongir, Telangana – 508252, IN
5 Department of Pharmaceutics, Anwarul Uloom College of Pharmacy, Newmallepally, Hyderabad, Telangana, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 9, No 4 (2017), Pagination: 147-157Abstract
Osmotic drug delivery system (ODDS) provides the drug dose and dosing interval in optimized manner to maintain drug concentration within therapeutic window thus ensuring efficacy and minimizing toxic effects. The objective of ODDS is to release pharmacologically active ingredients in a predetermined, predictable and reproducible manner to systemic circulation. ODDS delivers a drug to large extent is independent of the physiological factors of the gastrointestinal tract, pH. Hence it can be utilized for systemic as well as targeted delivery of drugs. The release of drugs from osmotic system controls the drug release by controlling various formulation factors such as solubility, osmotic pressure of the core components, size of the delivery orifice and nature of the rate controlling membrane. The design of osmotic system is achieved by optimizing formulation and processing factors to deliver drugs in preprogrammed rate and controlled manner. In present study is an update on osmosis, different types of osmotic systems, components of ODDS, key parameter sand some patents.Keywords
Osmotic Drug Delivery System, Osmosis, Osmotic Pressure.References
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- Formulation and Evaluation of Immediate Release Tablets of Topiramate using Sodium Starch Glycolate
Abstract Views :209 |
PDF Views:0
Authors
Kanhu Charan Panda
1,
Niranjan Panda
1,
Chinmaya Keshari Sahoo
2,
Jimidi Bhaskar
3,
D. Venkata Ramana
4
Affiliations
1 Department of Pharmaceutics, Anwar-ul-Uloom College of Pharmacy, Hyderabad, Telangana-500001, IN
2 Department of Pharmaceutics, Malla Reddy College of Pharmacy (Affiliated to Osmania University), Maisammaguda, Secunderabad, Telangana-500014, IN
3 Department of Pharmaceutics, KLR Pharmacy College, Paloncha, Bhadradri, Kothagudem, Telangana-507115, IN
4 Department of Pharmaceutical Technology, Samskruti College of Pharmacy, Kondapur, Ghatkesar, Medchal, Telangana, IN
1 Department of Pharmaceutics, Anwar-ul-Uloom College of Pharmacy, Hyderabad, Telangana-500001, IN
2 Department of Pharmaceutics, Malla Reddy College of Pharmacy (Affiliated to Osmania University), Maisammaguda, Secunderabad, Telangana-500014, IN
3 Department of Pharmaceutics, KLR Pharmacy College, Paloncha, Bhadradri, Kothagudem, Telangana-507115, IN
4 Department of Pharmaceutical Technology, Samskruti College of Pharmacy, Kondapur, Ghatkesar, Medchal, Telangana, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 6 (2019), Pagination: 3024-3028Abstract
The aim of the current study was to develop immediate release tablets (IRT) of topiramate using different concentrations of sodium starch glycolate (SSG) as super disintegrant. Four different formulations of IRT were prepared using wet granulation method. Different pre compression and post compression characterization of tablet was carried out. In vitro drug release studies were carried out in USP II paddle type dissolution apparatus for different formulation and the batch containing 7.5 mg of SSG per tablet gave maximum amount of drug release of 90.76% at the end of 50 mins. Drug and excipients compatibility studies were carried out through FTIR spectroscopy. FTIR spectroscopy studies revelled that there is no interaction between drug and different excipients used in formulation. Short term stability studies (at 40±2ºC/75±5% RH) on the best formulation indicated that there were no significant changes in release profile and drug content after a period of one to three month. Among all the formulations, F4 formulation was finally optimized.Keywords
IRT, Topiramate, SSG, Drug Release, FTIR Spectroscopy.References
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